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cheap oakley sunglasses Subclinical CIP may be common, diagnosis depending on the sensitivity of the diagnostic tests used, and the long term significance of this has not been elucidated. However, symptomatic CIP is rarely an early or dominant feature of SLE and severe pulmonary fibrosis is rare (fig2).13 Moderate or severe pulmonary fibrosis was present in only four of 120 necropsy specimens in patients with SLE.4 Histological features of CIP complicating SLE are non specific and include varying degrees of chronic inflammatory cell infiltrates, peribronchial lymphoid hyperplasia, interstitial fibrosis, and hyperplasia of type II pneumocytes.3Clinical and serological parameters fail to correlate with the nature or extent of pulmonary functional abnormalities.3 An association between anti SS A antibodies and chronic lupus pneumonitis was suggested in one study in which 81% of patients with lupus pneumonitis had anti SS A (Ro) antibodies5; others found no correlation between serological abnormalities (anti SS A, anti SS B, anti Sm) and pulmonary function tests.22 Anti U1 RNP antibodies were associated with reduced lung volumes and transfer factor in one study; Sm antibodies did not correlate with pulmonary functional impairment.23 The presence of scleroderma like traits for example, Raynaud’s phenomenon, swollen fingers, sclerodactyly, telangiectasia, dyspnoea, nailfold capillary abnormalities among patients with SLE was associated with a higher prevalence of restrictive defects or reduced transfer factor.23 Progressive severe CIP rarely complicates SLE but may be seen in a subset of patients with SLE in the context of overlap syndrome.Chronic interstitial pneumonia in a 35 year old woman with SLE. HRCT scan shows extensive ground glass opacities admixed with coarse linear bands and honeycomb cysts cheap oakley sunglasses.


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